منابع مشابه
Microglia
may have different origins, i.e. those arising from the primitive macrophages from the yolk sac and those newly differentiated from monocytes or their progenitors. Over 95% of all microglia are generated after birth and after the formation of the blood–brain barrier (BBB) and there has been an ongoing debate regarding the maintenance of the microglial population in the adult CNS. One hypothesis...
متن کاملMicroglia as a stem cell
Microglia is considered the only cell population of mesodermal origin, which comprises 10% of the cells in brain parenchyma. Recent neural stem cell (NSC) studies demonstrate that the brain has regenerative potential. NSCs do not give rise to microglial cells, however indicating that NSCs alone cannot complete the regenetion of the brain. Although the role of microglia is not fully understood, ...
متن کاملMicroglia as a stem cell
Microglia is considered the only cell population of mesodermal origin, which comprises 10% of the cells in brain parenchyma. Recent neural stem cell (NSC) studies demonstrate that the brain has regenerative potential. NSCs do not give rise to microglial cells, however indicating that NSCs alone cannot complete the regenetion of the brain. Although the role of microglia is not fully understood, ...
متن کاملWNT SIGNALING IN MICROGLIA WNTs as novel regulators of microglia
Microglia, the immunocompetent cells of the central nervous system (CNS) and the brain’s own macrophages are the most motile cells in the CNS and those with highest plasticity, as they rapidly move their projections to actively screen their environment for any type of injury. Upon cell damage or infection, microglia respond quickly: they proliferate, change morphology from ramified to amoeboid ...
متن کاملP108: Microglia in Traumatic Brain Injury
Microglia is one of the first innate immune components. These cells account about 5 to 10% of the entire adult brain cells and are activated by trauma. Complex-mediated inflammatory responses occur through cellular and molecular events during and after the traumatic brain injury (TBI). In-lesion area astrocytes, microglia, and damaged neurons begin to secrete cytokines and chemokines. Microglia...
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ژورنال
عنوان ژورنال: Lab Animal
سال: 2018
ISSN: 0093-7355,1548-4475
DOI: 10.1038/s41684-018-0185-6